|
KMID : 1161519990030030337
|
|
Animal Cells and Systems
1999 Volume.3 No. 3 p.337 ~ p.341
|
|
|
Induction of cytotoxic T lymphocyte response against the core and NS3 genes of the hepatitis C virus in Balb/c mice
|
|
Kim Na-Young
Sohn He-Kwang
Choe Joon-Ho
Park Sang-Dai
Seong Rho-Hyun
|
|
|
Abstract
|
|
|
|
Hepatitis C virus (HCV) is a positive strand RNA virus of the Flaviviridae family and the major cause of post?transfusion non?A, non?B hepatitis. Vaccine development for HCV is essential but has been slowed by poor understanding of the type of immunity that naturally terminates HCV infection. The DNA?based immunization technique offers the potential advantage of including cellular immune responses against conserved internal proteins of a virus, as well as the generation of antibodies to viral surface proteins. Here, we demonstrate that cell lines expressing the HCV core and/or NS3 proteins can induce a specific CTL response in mice, and these results suggest a possibility that the HCV core and NS3 DNA can be used to induce CTL activity against the antigen in mice and can be further developed as a therapeutic and preventive DNA vaccine.
|
|
|
KEYWORD
|
|
|
Hepatitis C virus, Cytotoxic T lymphocyte, DNA vaccine
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|